Assay Detail
Functional
CHEMBL4671795
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Antiproliferative activity against human MINO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MINO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.98 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747905 | — | — | 1 | 6.60 |
| CHEMBL4740190 | — | — | 1 | 6.40 |
| CHEMBL4755273 | — | — | 1 | 6.22 |
| CHEMBL4748930 | — | — | 1 | 6.10 |
| CHEMBL4740083 | — | — | 1 | 6.05 |
| CHEMBL4788575 | — | — | 1 | 5.58 |
| CHEMBL4759381 | — | — | 1 | 5.47 |
| CHEMBL4762893 | — | — | 1 | 5.40 |
| CHEMBL4760425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747905 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4740190 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4755273 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4748930 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4740083 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4788575 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4759381 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4762893 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4760425 | — | IC50 | > | 10000.0 | nM | - |