Assay Detail
Functional
CHEMBL4671906
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Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 mins by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 10.39 | 10.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755815 | — | — | 1 | 10.83 |
| CHEMBL4098061 | — | — | 1 | 10.74 |
| CHEMBL4761047 | — | — | 1 | 10.60 |
| CHEMBL4745985 | — | — | 1 | 10.32 |
| CHEMBL4745235 | — | — | 1 | 10.12 |
| CHEMBL4762061 | — | — | 1 | 9.71 |
| CHEMBL4751319 | — | — | 1 | - |
| CHEMBL4758415 | — | — | 1 | - |
| CHEMBL4756489 | — | — | 1 | - |
| CHEMBL4757675 | — | — | 1 | - |
| CHEMBL4741348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755815 | — | EC50 | = | 0.0147 | nM | 10.83 |
| CHEMBL4098061 | — | EC50 | = | 0.0183 | nM | 10.74 |
| CHEMBL4761047 | — | EC50 | = | 0.0249 | nM | 10.60 |
| CHEMBL4745985 | — | EC50 | = | 0.0475 | nM | 10.32 |
| CHEMBL4745235 | — | EC50 | = | 0.0754 | nM | 10.12 |
| CHEMBL4762061 | — | EC50 | = | 0.194 | nM | 9.71 |
| CHEMBL4751319 | — | EC50 | = | 0.00813 | nM | - |
| CHEMBL4758415 | — | EC50 | = | 0.0064 | nM | - |
| CHEMBL4756489 | — | EC50 | = | 0.0012 | nM | - |
| CHEMBL4757675 | — | EC50 | = | 0.0004 | nM | - |
| CHEMBL4741348 | — | EC50 | = | 0.0074 | nM | - |