Assay Detail
Binding
CHEMBL4671982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TrxR in human BEL-7402/5-FU cells by colorimetric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BEL-7402/5-FU |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thioredoxin reductase 1, cytoplasmic (CHEMBL1927) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757091 | — | — | 1 | 6.70 |
| CHEMBL4755909 | — | — | 1 | 6.70 |
| CHEMBL4798017 | — | — | 1 | 6.40 |
| CHEMBL4763453 | — | — | 1 | 6.22 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757091 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4755909 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4798017 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4763453 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 1800.0 | nM | 5.75 |