Assay Detail
Functional
CHEMBL4672273
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Antitumor activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.49 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.38 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.38 |
| CHEMBL4751362 | — | — | 1 | 5.20 |
| CHEMBL4776730 | — | — | 1 | 5.15 |
| CHEMBL4751085 | — | — | 1 | 5.03 |
| CHEMBL1545480 | — | — | 1 | 4.98 |
| CHEMBL1619395 | — | — | 1 | 4.90 |
| CHEMBL4755988 | — | — | 1 | 4.83 |
| CHEMBL4740108 | — | — | 1 | 4.78 |
| CHEMBL4755651 | — | — | 1 | 4.76 |
| CHEMBL4787698 | — | — | 1 | 4.71 |
| CHEMBL4760641 | — | — | 1 | 4.67 |
| CHEMBL4776495 | — | — | 1 | 4.64 |
| CHEMBL4795485 | — | — | 1 | 4.62 |
| CHEMBL4763033 | — | — | 1 | 4.57 |
| CHEMBL4763255 | — | — | 1 | 4.54 |
| CHEMBL4793255 | — | — | 1 | 4.52 |
| CHEMBL4777662 | — | — | 1 | 4.49 |
| CHEMBL4764731 | — | — | 1 | 4.44 |
| CHEMBL4763631 | — | — | 1 | 4.42 |
| CHEMBL4789169 | — | — | 1 | 4.40 |
| CHEMBL4784504 | — | — | 1 | 4.37 |
| CHEMBL4777234 | — | — | 1 | 4.36 |
| CHEMBL4752564 | — | — | 1 | 4.35 |
| CHEMBL4750114 | — | — | 1 | 4.34 |
| CHEMBL4783527 | — | — | 1 | 4.32 |
| CHEMBL4796827 | — | — | 1 | 4.31 |
| CHEMBL4781842 | — | — | 1 | 4.29 |
| CHEMBL4754033 | — | — | 1 | 4.26 |
| CHEMBL4758734 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4751362 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL4776730 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL4751085 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL1545480 | — | IC50 | = | 10390.0 | nM | 4.98 |
| CHEMBL1619395 | — | IC50 | = | 12620.0 | nM | 4.90 |
| CHEMBL4755988 | — | IC50 | = | 14810.0 | nM | 4.83 |
| CHEMBL4740108 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4755651 | — | IC50 | = | 17160.0 | nM | 4.76 |
| CHEMBL4787698 | — | IC50 | = | 19630.0 | nM | 4.71 |
| CHEMBL4760641 | — | IC50 | = | 21450.0 | nM | 4.67 |
| CHEMBL4776495 | — | IC50 | = | 22960.0 | nM | 4.64 |
| CHEMBL4795485 | — | IC50 | = | 24170.0 | nM | 4.62 |
| CHEMBL4763033 | — | IC50 | = | 27050.0 | nM | 4.57 |
| CHEMBL4763255 | — | IC50 | = | 29060.0 | nM | 4.54 |
| CHEMBL4793255 | — | IC50 | = | 30280.0 | nM | 4.52 |
| CHEMBL4777662 | — | IC50 | = | 32490.0 | nM | 4.49 |
| CHEMBL4764731 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL4763631 | — | IC50 | = | 37730.0 | nM | 4.42 |
| CHEMBL4789169 | — | IC50 | = | 39560.0 | nM | 4.40 |
| CHEMBL4784504 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL4777234 | — | IC50 | = | 44160.0 | nM | 4.36 |
| CHEMBL4752564 | — | IC50 | = | 44830.0 | nM | 4.35 |
| CHEMBL4750114 | — | IC50 | = | 45680.0 | nM | 4.34 |
| CHEMBL4783527 | — | IC50 | = | 47850.0 | nM | 4.32 |
| CHEMBL4796827 | — | IC50 | = | 48870.0 | nM | 4.31 |
| CHEMBL4781842 | — | IC50 | = | 51920.0 | nM | 4.29 |
| CHEMBL4754033 | — | IC50 | = | 55370.0 | nM | 4.26 |
| CHEMBL4758734 | — | IC50 | = | 56160.0 | nM | 4.25 |
| CHEMBL4791100 | — | IC50 | = | 59330.0 | nM | 4.23 |
| CHEMBL4742224 | — | IC50 | = | 59810.0 | nM | 4.22 |
| CHEMBL4743431 | — | IC50 | = | 61320.0 | nM | 4.21 |
| CHEMBL1566416 | — | IC50 | = | 65070.0 | nM | 4.19 |
| CHEMBL4761231 | — | IC50 | = | 64940.0 | nM | 4.19 |
| CHEMBL4777124 | — | IC50 | = | 67590.0 | nM | 4.17 |
| CHEMBL4755275 | — | IC50 | = | 68740.0 | nM | 4.16 |
| CHEMBL4777136 | — | IC50 | = | 70580.0 | nM | 4.15 |
| CHEMBL4740528 | — | IC50 | = | 74620.0 | nM | 4.13 |
| CHEMBL4740589 | — | IC50 | = | 78160.0 | nM | 4.11 |
| CHEMBL4746036 | — | IC50 | = | 81750.0 | nM | 4.09 |
| CHEMBL4748256 | — | IC50 | = | 88300.0 | nM | 4.05 |
| CHEMBL4782849 | — | IC50 | = | 92160.0 | nM | 4.04 |
| CHEMBL4740969 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4757330 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4796614 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760503 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795620 | — | IC50 | > | 100000.0 | nM | - |