Assay Detail
Binding
CHEMBL4672528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human kidney glutaminase assessed as reduction in glutamate production in presence of NADPH-dependent glutamate dehydrogenase preincubated 60 mins by coupled biochemical assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.72 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177757 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177757 | — | IC50 | = | 190.0 | nM | 6.72 |