Assay Detail
Functional
CHEMBL4672532
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Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as reduction in HBsAg level in cell supernatants incubated for 5 days by AlphaLisa assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of DHQ-based chemical biology probe to profile cellular targets for HBV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.52 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284226 | — | — | 1 | 8.89 |
| CHEMBL4763411 | — | — | 1 | 8.65 |
| CHEMBL4756381 | — | — | 1 | 8.25 |
| CHEMBL4743215 | — | — | 1 | 8.24 |
| CHEMBL4745563 | — | — | 1 | 6.81 |
| CHEMBL4760093 | — | — | 1 | 6.51 |
| CHEMBL4777836 | — | — | 1 | 6.43 |
| CHEMBL4796221 | — | — | 1 | 6.38 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284226 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4763411 | — | EC50 | = | 2.25 | nM | 8.65 |
| CHEMBL4756381 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4743215 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4745563 | — | EC50 | = | 154.4 | nM | 6.81 |
| CHEMBL4760093 | — | EC50 | = | 305.2 | nM | 6.51 |
| CHEMBL4777836 | — | EC50 | = | 367.4 | nM | 6.43 |
| CHEMBL4796221 | — | EC50 | = | 412.1 | nM | 6.38 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | > | 1000.0 | nM | - |