Assay Detail
Binding
CHEMBL4673433
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Inhibition of bacterial ImiS expressed in Escherichia coli BL21 (DE3) using imipenem as substrate preincubated for 3 hrs with enzyme followed by substrate addition by spectrometry analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
meta-Substituted benzenesulfonamide: a potent scaffold for the development of metallo-beta-lactamase ImiS inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.80 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751785 | — | — | 1 | 6.96 |
| CHEMBL4783335 | — | — | 1 | 6.85 |
| CHEMBL4749373 | — | — | 1 | 6.82 |
| CHEMBL4764010 | — | — | 1 | 6.80 |
| CHEMBL203112 | — | — | 1 | 6.64 |
| CHEMBL4786181 | — | — | 1 | 6.51 |
| CHEMBL4750797 | — | — | 1 | 6.36 |
| CHEMBL4749633 | — | — | 1 | 6.07 |
| CHEMBL4753318 | — | — | 1 | 5.57 |
| CHEMBL425044 | — | — | 1 | 5.48 |
| CHEMBL1389382 | — | — | 1 | 5.46 |
| CHEMBL4753772 | — | — | 1 | 5.39 |
| CHEMBL204326 | — | — | 1 | 5.34 |
| CHEMBL4763689 | — | — | 1 | 5.32 |
| CHEMBL4754911 | — | — | 1 | 5.29 |
| CHEMBL4778250 | — | — | 1 | 5.27 |
| CHEMBL4783220 | — | — | 1 | 5.25 |
| CHEMBL4790471 | — | — | 1 | 5.17 |
| CHEMBL4790918 | — | — | 1 | 5.14 |
| CHEMBL23559 | — | — | 1 | 5.12 |
| CHEMBL4756088 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751785 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4783335 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4749373 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4764010 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL203112 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4786181 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4750797 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4749633 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4753318 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL425044 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1389382 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4753772 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL204326 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4763689 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4754911 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4778250 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4783220 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4790471 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4790918 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL23559 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4756088 | — | IC50 | = | 9300.0 | nM | 5.03 |