Assay Detail

CHEMBL4674543

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Binding

Covalent inhibition of GST-tagged bacterial NDM-1 expressed in Escherichia coli BL21 (DE3)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bacteria
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.

Jin WB,Xu C,Cheng Q,Qi XL,Gao W,Zheng Z,Chan EWC,Leung YC,Chan TH,Wong KY,Chen S,Chan KF
Eur J Med Chem (2018) 155 : 285 -302
PubMed 29894943 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.10	5.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL434965	D-CAPTOPRIL	—	1	5.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL434965	D-CAPTOPRIL	IC50	=	7900.0	nM	5.10