Assay Detail
Functional
CHEMBL4675239
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Antiproliferative activity against human MCF-7 cells overexpressing CYP1A1 assessed as reduction in cell viability
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.19 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577397 | PONGAPIN | — | 1 | 6.22 |
| CHEMBL224157 | LANCEOLATIN B | — | 1 | 6.16 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577397 | PONGAPIN | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL224157 | LANCEOLATIN B | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | EC50 | > | 20000.0 | nM | - |