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Assay Detail

CHEMBL4675293

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Binding
Non-covalent reversible inhibition of human CSE
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cystathionine gamma-lyase (CHEMBL4295745)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase.
Hu Y,Wang L,Han X,Zhou Y,Zhang T,Wang L,Hong T,Zhang W,Guo XX,Sun J,Qi Y,Yu J,Liu H,Wu F
J Med Chem (2019) 62 : 1677 -1683
PubMed 30562026 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Inhibition 1 - -
IC50 1 5.21 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4761159 1 5.21
CHEMBL275938 AURINTRICARBOXYLIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4761159 IC50 = 6200.0 nM 5.21
CHEMBL275938 AURINTRICARBOXYLIC ACID Inhibition - % -