Assay Detail
Binding
CHEMBL4675680
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Binding affinity to ZAP70 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.13 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786316 | — | — | 1 | 7.85 |
| CHEMBL4751083 | — | — | 1 | 7.14 |
| CHEMBL4753164 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786316 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL4751083 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL4753164 | — | Kd | = | 400.0 | nM | 6.40 |