Assay Detail
Functional
CHEMBL4676239
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.41 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.17 |
| CHEMBL4761842 | — | — | 1 | 6.11 |
| CHEMBL4789516 | — | — | 1 | 6.04 |
| CHEMBL4782768 | — | — | 1 | 6.02 |
| CHEMBL4748626 | — | — | 1 | 5.98 |
| CHEMBL4798277 | — | — | 1 | 5.98 |
| CHEMBL4753554 | — | — | 1 | 5.90 |
| CHEMBL4752803 | — | — | 1 | 5.79 |
| CHEMBL4741674 | — | — | 1 | 5.66 |
| CHEMBL4798474 | — | — | 1 | 5.63 |
| CHEMBL4782492 | — | — | 1 | 5.43 |
| CHEMBL1829021 | — | — | 1 | 4.81 |
| CHEMBL89700 | METHYLHONOKIOL | — | 1 | 4.76 |
| CHEMBL1814303 | — | — | 1 | 4.72 |
| CHEMBL1829018 | — | — | 1 | 4.72 |
| CHEMBL16901 | HONOKIOL | — | 1 | 4.62 |
| CHEMBL90397 | — | — | 1 | 4.53 |
| CHEMBL4788150 | — | — | 1 | 4.53 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4761842 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4789516 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4782768 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4748626 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4798277 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4753554 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4752803 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4741674 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4798474 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4782492 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL1829021 | — | IC50 | = | 15480.0 | nM | 4.81 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 17470.0 | nM | 4.76 |
| CHEMBL1814303 | — | IC50 | = | 19180.0 | nM | 4.72 |
| CHEMBL1829018 | — | IC50 | = | 19110.0 | nM | 4.72 |
| CHEMBL16901 | HONOKIOL | IC50 | = | 23850.0 | nM | 4.62 |
| CHEMBL90397 | — | IC50 | = | 29650.0 | nM | 4.53 |
| CHEMBL4788150 | — | IC50 | = | 29270.0 | nM | 4.53 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | > | 50000.0 | nM | - |