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Assay Detail

CHEMBL4676243

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ADMET
Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type L02
Confidence 1 — Organism
Curated By Autocuration

Target

L02 (CHEMBL4296457)
Type CELL-LINE
Organism Homo sapiens

Publication

Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine.
Shi X,Zhang T,Lou H,Song H,Li C,Fan P
J Med Chem (2020) 63 : 11786 -11800
PubMed 32996316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.16 5.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.65
CHEMBL4748626 1 5.53
CHEMBL4798474 1 5.52
CHEMBL4782768 1 5.52
CHEMBL4798277 1 5.46
CHEMBL4741674 1 5.45
CHEMBL4789516 1 5.44
CHEMBL4752803 1 5.34
CHEMBL4761842 1 5.32
CHEMBL4782492 1 5.28
CHEMBL4753554 1 5.24
CHEMBL1829021 1 4.65
CHEMBL89700 METHYLHONOKIOL 1 4.62
CHEMBL16901 HONOKIOL 1 4.59
CHEMBL1829018 1 4.55
CHEMBL90397 1 4.45
CHEMBL12089 BERBERINE CHLORIDE 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 2240.0 nM 5.65
CHEMBL4748626 IC50 = 2970.0 nM 5.53
CHEMBL4798474 IC50 = 3040.0 nM 5.52
CHEMBL4782768 IC50 = 3050.0 nM 5.52
CHEMBL4798277 IC50 = 3430.0 nM 5.46
CHEMBL4741674 IC50 = 3560.0 nM 5.45
CHEMBL4789516 IC50 = 3620.0 nM 5.44
CHEMBL4752803 IC50 = 4610.0 nM 5.34
CHEMBL4761842 IC50 = 4820.0 nM 5.32
CHEMBL4782492 IC50 = 5210.0 nM 5.28
CHEMBL4753554 IC50 = 5770.0 nM 5.24
CHEMBL1829021 IC50 = 22350.0 nM 4.65
CHEMBL89700 METHYLHONOKIOL IC50 = 23940.0 nM 4.62
CHEMBL16901 HONOKIOL IC50 = 25490.0 nM 4.59
CHEMBL1829018 IC50 = 27830.0 nM 4.55
CHEMBL90397 IC50 = 35270.0 nM 4.45
CHEMBL12089 BERBERINE CHLORIDE IC50 > 50000.0 nM -