Assay Detail
Functional
CHEMBL4676314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as reduction in bacterial growth by serial dilution method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Acinetobacter baumannii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.53 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1454910 | NITROXOLINE | 4.0 | 1 | 5.60 |
| CHEMBL1971965 | — | — | 1 | 4.27 |
| CHEMBL4798191 | — | — | 1 | 4.14 |
| CHEMBL4172085 | — | — | 1 | 4.09 |
| CHEMBL521258 | — | — | 1 | - |
| CHEMBL472882 | — | — | 1 | - |
| CHEMBL479593 | — | — | 1 | - |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | - |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1454910 | NITROXOLINE | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1971965 | — | EC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4798191 | — | EC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4172085 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL521258 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL472882 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL479593 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244888 | NIFUROXAZIDE | EC50 | > | 100000.0 | nM | - |
| CHEMBL572 | NITROFURANTOIN | EC50 | > | 100000.0 | nM | - |