Assay Detail
Binding
CHEMBL4676491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human uPA using Tos-Gly-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777212 | — | — | 1 | 5.53 |
| CHEMBL4754247 | — | — | 1 | 5.17 |
| CHEMBL4748137 | — | — | 1 | 5.10 |
| CHEMBL4776259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777212 | — | IC50 | = | 2942.0 | nM | 5.53 |
| CHEMBL4754247 | — | IC50 | = | 6762.0 | nM | 5.17 |
| CHEMBL4748137 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL4776259 | — | IC50 | > | 5000.0 | nM | - |