Assay Detail
Binding
CHEMBL4676493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasmin using Mes-dArg-Phe-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.59 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777212 | — | — | 1 | 4.59 |
| CHEMBL4786270 | — | — | 1 | - |
| CHEMBL4754247 | — | — | 1 | - |
| CHEMBL4776259 | — | — | 1 | - |
| CHEMBL4748137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777212 | — | IC50 | = | 25820.0 | nM | 4.59 |
| CHEMBL4786270 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4754247 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4776259 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4748137 | — | IC50 | > | 5000.0 | nM | - |