Assay Detail
Binding
CHEMBL4676842
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Agonist activity at nAChR in rat striatal synaptosomes assessed as [3H]dopamine release
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyridine alkaloids with activity in the central nervous system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 7.00 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.96 |
| CHEMBL4779424 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL274525 | ABT-418 | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4779424 | — | EC50 | = | 1200.0 | nM | 5.92 |