Assay Detail
Binding
CHEMBL4676863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3H-cytisine from rat brain alpha4beta2 nAChR by radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Pyridine alkaloids with activity in the central nervous system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.75 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.25 |
| CHEMBL1496898 | — | — | 1 | 6.04 |
| CHEMBL1526229 | ANABASINE | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL1496898 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL1526229 | ANABASINE | Ki | = | 1100.0 | nM | 5.96 |