Assay Detail
Functional
CHEMBL4677016
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Cytotoxicity against human MES SA/DX5 cells assessed as reduction in cell viability
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of PNU-159682 antibody drug conjugates (ADCs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 10.18 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797377 | — | — | 1 | 11.00 |
| CHEMBL4756044 | — | — | 1 | 9.95 |
| CHEMBL4795022 | — | — | 1 | 9.90 |
| CHEMBL4796838 | — | — | 1 | 9.86 |
| CHEMBL4777727 | — | — | 1 | - |
| CHEMBL4799865 | — | — | 1 | - |
| CHEMBL4784749 | — | — | 1 | - |
| CHEMBL4795471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797377 | — | EC50 | = | 0.0101 | nM | 11.00 |
| CHEMBL4756044 | — | EC50 | = | 0.113 | nM | 9.95 |
| CHEMBL4795022 | — | EC50 | = | 0.125 | nM | 9.90 |
| CHEMBL4796838 | — | EC50 | = | 0.139 | nM | 9.86 |
| CHEMBL4777727 | — | EC50 | = | 0.00038 | nM | - |
| CHEMBL4799865 | — | EC50 | = | 0.0009 | nM | - |
| CHEMBL4784749 | — | EC50 | > | 15.0 | nM | - |
| CHEMBL4795471 | — | EC50 | > | 0.3 | nM | - |