Assay Detail
ADMET
CHEMBL4677017
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of PNU-159682 antibody drug conjugates (ADCs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 10.46 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4797377 | — | — | 1 | 10.92 |
| CHEMBL4795471 | — | — | 1 | 10.62 |
| CHEMBL4784749 | — | — | 1 | 10.48 |
| CHEMBL4796838 | — | — | 1 | 10.29 |
| CHEMBL4795022 | — | — | 1 | 10.28 |
| CHEMBL4756044 | — | — | 1 | 10.19 |
| CHEMBL4777727 | — | — | 1 | - |
| CHEMBL4799865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4797377 | — | EC50 | = | 0.012 | nM | 10.92 |
| CHEMBL4795471 | — | EC50 | = | 0.024 | nM | 10.62 |
| CHEMBL4784749 | — | EC50 | = | 0.033 | nM | 10.48 |
| CHEMBL4796838 | — | EC50 | = | 0.051 | nM | 10.29 |
| CHEMBL4795022 | — | EC50 | = | 0.052 | nM | 10.28 |
| CHEMBL4756044 | — | EC50 | = | 0.065 | nM | 10.19 |
| CHEMBL4777727 | — | EC50 | = | 0.00037 | nM | - |
| CHEMBL4799865 | — | EC50 | = | 0.00069 | nM | - |