Assay Detail
Binding
CHEMBL4677471
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Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel antipsychotic trans-4-(2-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexan-1-amine derivatives targeting dopamine/serotonin receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.70 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 9.31 |
| CHEMBL4759975 | — | — | 1 | 8.55 |
| CHEMBL4741702 | — | — | 1 | 8.54 |
| CHEMBL4752414 | — | — | 1 | 8.24 |
| CHEMBL4799863 | — | — | 1 | 8.23 |
| CHEMBL4797996 | — | — | 1 | 8.20 |
| CHEMBL4756826 | — | — | 1 | 8.01 |
| CHEMBL4753808 | — | — | 1 | 7.92 |
| CHEMBL4762024 | — | — | 1 | 7.85 |
| CHEMBL4745809 | — | — | 1 | 7.69 |
| CHEMBL4750939 | — | — | 1 | 7.62 |
| CHEMBL4741673 | — | — | 1 | 7.60 |
| CHEMBL4784751 | — | — | 1 | 7.50 |
| CHEMBL4788140 | — | — | 1 | 7.36 |
| CHEMBL4761274 | — | — | 1 | 7.08 |
| CHEMBL4743651 | — | — | 1 | 7.04 |
| CHEMBL4780335 | — | — | 1 | 7.03 |
| CHEMBL4762918 | — | — | 1 | 7.00 |
| CHEMBL4755563 | — | — | 1 | 6.72 |
| CHEMBL4779912 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL4759975 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4741702 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4752414 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4799863 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4797996 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4756826 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL4753808 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL4762024 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL4745809 | — | Ki | = | 20.6 | nM | 7.69 |
| CHEMBL4750939 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL4741673 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL4784751 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL4788140 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL4761274 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL4743651 | — | Ki | = | 91.1 | nM | 7.04 |
| CHEMBL4780335 | — | Ki | = | 93.9 | nM | 7.03 |
| CHEMBL4762918 | — | Ki | = | 99.3 | nM | 7.00 |
| CHEMBL4755563 | — | Ki | = | 188.7 | nM | 6.72 |
| CHEMBL4779912 | — | Ki | = | 290.5 | nM | 6.54 |