Assay Detail
Functional
CHEMBL4677484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of novel acridone derivatives as antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.37 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792746 | — | — | 1 | 6.52 |
| CHEMBL338604 | C-1311 | 2.0 | 1 | 6.32 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.22 |
| CHEMBL4751400 | — | — | 1 | 5.96 |
| CHEMBL4785791 | — | — | 1 | 5.92 |
| CHEMBL4753685 | — | — | 1 | 5.70 |
| CHEMBL4755794 | — | — | 1 | 5.64 |
| CHEMBL4763250 | — | — | 1 | 5.64 |
| CHEMBL4754463 | — | — | 1 | 5.62 |
| CHEMBL4757404 | — | — | 1 | 5.42 |
| CHEMBL4753138 | — | — | 1 | 5.19 |
| CHEMBL4778088 | — | — | 1 | 5.07 |
| CHEMBL4760484 | — | — | 1 | 5.06 |
| CHEMBL4750575 | — | — | 1 | 5.06 |
| CHEMBL4789243 | — | — | 1 | 4.95 |
| CHEMBL4753198 | — | — | 1 | 4.93 |
| CHEMBL4762672 | — | — | 1 | 4.91 |
| CHEMBL4739992 | — | — | 1 | 4.81 |
| CHEMBL4781831 | — | — | 1 | 4.81 |
| CHEMBL4790142 | — | — | 1 | 4.80 |
| CHEMBL4746783 | — | — | 1 | 4.77 |
| CHEMBL4746105 | — | — | 1 | 4.71 |
| CHEMBL4762278 | — | — | 1 | - |
| CHEMBL4751053 | — | — | 1 | - |
| CHEMBL4786225 | — | — | 1 | - |
| CHEMBL4786121 | — | — | 1 | - |
| CHEMBL4786385 | — | — | 1 | - |
| CHEMBL4764037 | — | — | 1 | - |
| CHEMBL4789356 | — | — | 1 | - |
| CHEMBL4754670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792746 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL338604 | C-1311 | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4751400 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4785791 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4753685 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4755794 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4763250 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4754463 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4757404 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4753138 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4778088 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4760484 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4750575 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4789243 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4753198 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4762672 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4739992 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL4781831 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4790142 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4746783 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4746105 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4744119 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4798557 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4745058 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4799982 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4763208 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4744744 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4749689 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4740603 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784201 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4798006 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4760194 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4760711 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4753477 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4777087 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4790185 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4754670 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4789356 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4764037 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4786385 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4786121 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4786225 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4751053 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4762278 | — | IC50 | > | 20000.0 | nM | - |