Assay Detail
Binding
CHEMBL4677633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.72 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796600 | — | — | 1 | 8.52 |
| CHEMBL4741912 | — | — | 1 | 8.30 |
| CHEMBL4746440 | — | — | 1 | 8.30 |
| CHEMBL4782961 | — | — | 1 | 8.22 |
| CHEMBL4758769 | — | — | 1 | 8.15 |
| CHEMBL4748400 | — | — | 1 | 7.89 |
| CHEMBL4779423 | — | — | 1 | 7.89 |
| CHEMBL4778997 | — | — | 1 | 7.89 |
| CHEMBL4795918 | — | — | 1 | 7.85 |
| CHEMBL4799009 | — | — | 1 | 7.85 |
| CHEMBL4794151 | — | — | 1 | 7.85 |
| CHEMBL4792540 | — | — | 1 | 7.80 |
| CHEMBL4793366 | — | — | 1 | 7.77 |
| CHEMBL4800057 | — | — | 1 | 7.72 |
| CHEMBL4789210 | — | — | 1 | 7.70 |
| CHEMBL4748802 | — | — | 1 | 7.68 |
| CHEMBL4754535 | — | — | 1 | 7.64 |
| CHEMBL4776497 | — | — | 1 | 7.54 |
| CHEMBL4786152 | — | — | 1 | 7.52 |
| CHEMBL4750700 | — | — | 1 | 7.51 |
| CHEMBL4747695 | — | — | 1 | 7.47 |
| CHEMBL4787833 | — | — | 1 | 7.40 |
| CHEMBL4777354 | — | — | 1 | 7.38 |
| CHEMBL4755602 | — | — | 1 | 7.30 |
| CHEMBL4128069 | — | — | 1 | 6.89 |
| CHEMBL4794090 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796600 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4741912 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4746440 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4782961 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4758769 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4748400 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4779423 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4778997 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4795918 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4799009 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4794151 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4792540 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4793366 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4800057 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4789210 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4748802 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4754535 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4776497 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4786152 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4750700 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4747695 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4787833 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4777354 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4755602 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4128069 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4794090 | — | IC50 | = | 230.0 | nM | 6.64 |