Assay Detail
Binding
CHEMBL4677634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.84 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779423 | — | — | 1 | 6.48 |
| CHEMBL4795918 | — | — | 1 | 6.24 |
| CHEMBL4741912 | — | — | 1 | 6.23 |
| CHEMBL4789210 | — | — | 1 | 6.17 |
| CHEMBL4746440 | — | — | 1 | 6.13 |
| CHEMBL4128069 | — | — | 1 | 6.11 |
| CHEMBL4800057 | — | — | 1 | 5.99 |
| CHEMBL4782961 | — | — | 1 | 5.93 |
| CHEMBL4750700 | — | — | 1 | 5.92 |
| CHEMBL4778997 | — | — | 1 | 5.88 |
| CHEMBL4796600 | — | — | 1 | 5.87 |
| CHEMBL4748400 | — | — | 1 | 5.83 |
| CHEMBL4794151 | — | — | 1 | 5.83 |
| CHEMBL4787833 | — | — | 1 | 5.79 |
| CHEMBL4758769 | — | — | 1 | 5.79 |
| CHEMBL4786152 | — | — | 1 | 5.77 |
| CHEMBL4776497 | — | — | 1 | 5.71 |
| CHEMBL4747695 | — | — | 1 | 5.44 |
| CHEMBL4799009 | — | — | 1 | 5.35 |
| CHEMBL4755602 | — | — | 1 | 5.22 |
| CHEMBL4754535 | — | — | 1 | 5.01 |
| CHEMBL4793366 | — | — | 1 | - |
| CHEMBL4792540 | — | — | 1 | - |
| CHEMBL4777354 | — | — | 1 | - |
| CHEMBL4748802 | — | — | 1 | - |
| CHEMBL4794090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779423 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4795918 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL4741912 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL4789210 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL4746440 | — | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL4128069 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL4800057 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL4782961 | — | IC50 | = | 1168.0 | nM | 5.93 |
| CHEMBL4750700 | — | IC50 | = | 1215.0 | nM | 5.92 |
| CHEMBL4778997 | — | IC50 | = | 1327.0 | nM | 5.88 |
| CHEMBL4796600 | — | IC50 | = | 1361.0 | nM | 5.87 |
| CHEMBL4748400 | — | IC50 | = | 1464.0 | nM | 5.83 |
| CHEMBL4794151 | — | IC50 | = | 1477.0 | nM | 5.83 |
| CHEMBL4787833 | — | IC50 | = | 1611.0 | nM | 5.79 |
| CHEMBL4758769 | — | IC50 | = | 1602.0 | nM | 5.79 |
| CHEMBL4786152 | — | IC50 | = | 1713.0 | nM | 5.77 |
| CHEMBL4776497 | — | IC50 | = | 1926.0 | nM | 5.71 |
| CHEMBL4747695 | — | IC50 | = | 3631.0 | nM | 5.44 |
| CHEMBL4799009 | — | IC50 | = | 4475.0 | nM | 5.35 |
| CHEMBL4755602 | — | IC50 | = | 6038.0 | nM | 5.22 |
| CHEMBL4754535 | — | IC50 | = | 9838.0 | nM | 5.01 |
| CHEMBL4793366 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4792540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4777354 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4748802 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794090 | — | IC50 | > | 10000.0 | nM | - |