Assay Detail
Binding
CHEMBL4677635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK2 (CHEMBL5435) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.03 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779423 | — | — | 1 | 6.32 |
| CHEMBL4795918 | — | — | 1 | 6.16 |
| CHEMBL4746440 | — | — | 1 | 6.15 |
| CHEMBL4741912 | — | — | 1 | 6.14 |
| CHEMBL4800057 | — | — | 1 | 5.92 |
| CHEMBL4789210 | — | — | 1 | 5.88 |
| CHEMBL4128069 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779423 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL4795918 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4746440 | — | IC50 | = | 714.0 | nM | 6.15 |
| CHEMBL4741912 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4800057 | — | IC50 | = | 1193.0 | nM | 5.92 |
| CHEMBL4789210 | — | IC50 | = | 1329.0 | nM | 5.88 |
| CHEMBL4128069 | — | IC50 | = | 2448.0 | nM | 5.61 |