Assay Detail
Binding
CHEMBL4677637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK2 (CHEMBL5435) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.72 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741912 | — | — | 1 | 6.15 |
| CHEMBL4779423 | — | — | 1 | 5.94 |
| CHEMBL4746440 | — | — | 1 | 5.78 |
| CHEMBL4789210 | — | — | 1 | 5.77 |
| CHEMBL4795918 | — | — | 1 | 5.72 |
| CHEMBL4800057 | — | — | 1 | 5.37 |
| CHEMBL4128069 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741912 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL4779423 | — | IC50 | = | 1158.0 | nM | 5.94 |
| CHEMBL4746440 | — | IC50 | = | 1647.0 | nM | 5.78 |
| CHEMBL4789210 | — | IC50 | = | 1687.0 | nM | 5.77 |
| CHEMBL4795918 | — | IC50 | = | 1885.0 | nM | 5.72 |
| CHEMBL4800057 | — | IC50 | = | 4256.0 | nM | 5.37 |
| CHEMBL4128069 | — | IC50 | = | 4578.0 | nM | 5.34 |