Assay Detail
Physicochemical
CHEMBL4677667
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Glutathione peroxidase-like catalytic anti-lipid peroxidation activity assessed as inhibition of AAPH-induced lipid peroxidation incubated for 3 hrs using soybean lecithin/cholesterol-liposomes by TBARS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Physicochemical |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.54 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4760117 | — | — | 1 | 4.97 |
| CHEMBL4764857 | — | — | 1 | 4.88 |
| CHEMBL4741838 | — | — | 1 | 4.81 |
| CHEMBL4788779 | — | — | 1 | 4.78 |
| CHEMBL4749104 | — | — | 1 | 4.56 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | 4.53 |
| CHEMBL4759585 | — | — | 1 | 4.52 |
| CHEMBL4762545 | — | — | 1 | 4.38 |
| CHEMBL4762932 | — | — | 1 | 4.24 |
| CHEMBL3122204 | — | — | 1 | 4.15 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 4.09 |
| CHEMBL4755283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4760117 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4764857 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4741838 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL4788779 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4749104 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL290916 | EDARAVONE | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL4759585 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4762545 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL4762932 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL3122204 | — | IC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL51085 | EBSELEN | IC50 | = | 80400.0 | nM | 4.09 |
| CHEMBL4755283 | — | IC50 | = | 121200.0 | nM | - |