Assay Detail
Binding
CHEMBL4677729
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Inhibition of histidine-tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) using UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by Fluorescence plate reader analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase (CHEMBL3855) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.78 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752810 | — | — | 1 | 8.39 |
| CHEMBL4763699 | — | — | 1 | 8.36 |
| CHEMBL4779477 | — | — | 1 | 8.33 |
| CHEMBL4798463 | — | — | 1 | 8.15 |
| CHEMBL4795002 | — | — | 1 | 8.05 |
| CHEMBL4747965 | — | — | 1 | 7.70 |
| CHEMBL4750316 | — | — | 1 | 7.32 |
| CHEMBL4793599 | — | — | 1 | 6.88 |
| CHEMBL4794374 | — | — | 1 | 6.79 |
| CHEMBL4791421 | — | — | 1 | 6.25 |
| CHEMBL4795750 | — | — | 1 | 6.05 |
| CHEMBL4757624 | — | — | 1 | 5.85 |
| CHEMBL4759498 | — | — | 1 | 5.62 |
| CHEMBL4751265 | — | — | 1 | 5.41 |
| CHEMBL4747127 | — | — | 1 | 4.98 |
| CHEMBL4794206 | — | — | 1 | 4.98 |
| CHEMBL4177101 | — | — | 1 | 4.22 |
| CHEMBL4763800 | — | — | 1 | 3.97 |
| CHEMBL213493 | — | — | 1 | 3.96 |
| CHEMBL2285864 | — | — | 1 | 3.84 |
| CHEMBL4792585 | — | — | 1 | 3.67 |
| CHEMBL4792641 | — | — | 1 | 3.58 |
| CHEMBL4760487 | — | — | 1 | 3.33 |
| CHEMBL4800171 | — | — | 1 | 2.95 |
| CHEMBL379290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752810 | — | IC50 | = | 4.03 | nM | 8.39 |
| CHEMBL4763699 | — | IC50 | = | 4.42 | nM | 8.36 |
| CHEMBL4779477 | — | IC50 | = | 4.63 | nM | 8.33 |
| CHEMBL4798463 | — | IC50 | = | 7.04 | nM | 8.15 |
| CHEMBL4795002 | — | IC50 | = | 8.96 | nM | 8.05 |
| CHEMBL4747965 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4750316 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL4793599 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4794374 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4791421 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL4795750 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL4757624 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4759498 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4751265 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL4747127 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4794206 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4177101 | — | IC50 | = | 60400.0 | nM | 4.22 |
| CHEMBL4763800 | — | IC50 | = | 108000.0 | nM | 3.97 |
| CHEMBL213493 | — | IC50 | = | 111000.0 | nM | 3.96 |
| CHEMBL2285864 | — | IC50 | = | 144000.0 | nM | 3.84 |
| CHEMBL4792585 | — | IC50 | = | 214000.0 | nM | 3.67 |
| CHEMBL4792641 | — | IC50 | = | 261000.0 | nM | 3.58 |
| CHEMBL4760487 | — | IC50 | = | 466000.0 | nM | 3.33 |
| CHEMBL4800171 | — | IC50 | = | 1130000.0 | nM | 2.95 |
| CHEMBL379290 | — | IC50 | - | — | - |