Assay Detail
Binding
CHEMBL4677731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (S)-N-(2-(N-(3-biphenyl-4-ylcarboxamido-4-(hydroxyamino)-4-oxobutyl)sulfamoyl)ethyl)-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamide fluorescent probe from histidine tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of fluorscein probe measured after 2 hrs by fluorescence polarization assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase (CHEMBL3855) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.14 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750316 | — | — | 1 | 7.69 |
| CHEMBL4793599 | — | — | 1 | 7.57 |
| CHEMBL4794374 | — | — | 1 | 7.28 |
| CHEMBL4791421 | — | — | 1 | 7.03 |
| CHEMBL4795750 | — | — | 1 | 6.90 |
| CHEMBL4751265 | — | — | 1 | 6.26 |
| CHEMBL4794206 | — | — | 1 | 6.09 |
| CHEMBL4759498 | — | — | 1 | 5.75 |
| CHEMBL4755686 | — | — | 1 | 5.25 |
| CHEMBL4747127 | — | — | 1 | 5.19 |
| CHEMBL4744809 | — | — | 1 | 5.05 |
| CHEMBL4747065 | — | — | 1 | 4.89 |
| CHEMBL4763800 | — | — | 1 | 4.43 |
| CHEMBL4759491 | — | — | 1 | 4.42 |
| CHEMBL4792585 | — | — | 1 | 4.40 |
| CHEMBL4750538 | — | — | 1 | 4.40 |
| CHEMBL4177101 | — | — | 1 | 4.37 |
| CHEMBL4758755 | — | — | 1 | 4.26 |
| CHEMBL4792641 | — | — | 1 | 4.17 |
| CHEMBL2285864 | — | — | 1 | 3.93 |
| CHEMBL213493 | — | — | 1 | 3.90 |
| CHEMBL4742289 | — | — | 1 | 3.88 |
| CHEMBL4760487 | — | — | 1 | 3.59 |
| CHEMBL379290 | — | — | 1 | 2.56 |
| CHEMBL4800171 | — | — | 1 | - |
| CHEMBL4776312 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750316 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL4793599 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL4794374 | — | IC50 | = | 52.2 | nM | 7.28 |
| CHEMBL4791421 | — | IC50 | = | 92.9 | nM | 7.03 |
| CHEMBL4795750 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4751265 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL4794206 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL4759498 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4755686 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL4747127 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL4744809 | — | IC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL4747065 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4763800 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL4759491 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL4792585 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL4750538 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL4177101 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL4758755 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL4792641 | — | IC50 | = | 67800.0 | nM | 4.17 |
| CHEMBL2285864 | — | IC50 | = | 118000.0 | nM | 3.93 |
| CHEMBL213493 | — | IC50 | = | 125000.0 | nM | 3.90 |
| CHEMBL4742289 | — | IC50 | = | 132000.0 | nM | 3.88 |
| CHEMBL4760487 | — | IC50 | = | 259000.0 | nM | 3.59 |
| CHEMBL379290 | — | IC50 | = | 2780000.0 | nM | 2.56 |
| CHEMBL4800171 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL4776312 | — | IC50 | > | 100000.0 | nM | - |