Assay Detail
Binding
CHEMBL4677784
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Binding affinity to polybromo-1 (2) (unknown origin) by ITC analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.16 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790365 | — | — | 1 | 6.60 |
| CHEMBL4788561 | — | — | 1 | 6.38 |
| CHEMBL4793170 | — | — | 1 | 6.33 |
| CHEMBL4742007 | — | — | 1 | 6.05 |
| CHEMBL4780617 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790365 | — | Kd | = | 252.0 | nM | 6.60 |
| CHEMBL4788561 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL4793170 | — | Kd | = | 464.0 | nM | 6.33 |
| CHEMBL4742007 | — | Kd | = | 892.0 | nM | 6.05 |
| CHEMBL4780617 | — | Kd | = | 3655.0 | nM | 5.44 |