Assay Detail
Binding
CHEMBL4677903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stabilization Strategies for Linear Minigastrin Analogues: Further Improvements via the Inclusion of Proline into the Peptide Sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.07 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761587 | — | — | 1 | 9.40 |
| CHEMBL4759105 | — | — | 1 | 9.22 |
| CHEMBL4795198 | — | — | 1 | 9.05 |
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | 9.00 |
| CHEMBL4758706 | — | — | 1 | 8.89 |
| CHEMBL4795913 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761587 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4759105 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4795198 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1328 | PENTAGASTRIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4758706 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4795913 | — | IC50 | = | 1.4 | nM | 8.85 |