Assay Detail
Functional
CHEMBL4677904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stabilization Strategies for Linear Minigastrin Analogues: Further Improvements via the Inclusion of Proline into the Peptide Sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.06 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | 8.55 |
| CHEMBL4758706 | — | — | 1 | 7.91 |
| CHEMBL4795913 | — | — | 1 | 7.91 |
| CHEMBL4759105 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1328 | PENTAGASTRIN | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4758706 | — | EC50 | = | 12.38 | nM | 7.91 |
| CHEMBL4795913 | — | EC50 | = | 12.34 | nM | 7.91 |
| CHEMBL4759105 | — | EC50 | = | 14.23 | nM | 7.85 |