Assay Detail
Functional
CHEMBL4677935
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Antimicrobial activity against Entamoeba histolytica HM1:MMS assessed as reduction in amoeba growth
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Linearolactone and Kaempferol Disrupt the Actin Cytoskeleton in Entamoeba histolytica: Inhibition of Amoebic Liver Abscess Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.28 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.64 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 4.64 |
| CHEMBL4168251 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4168251 | — | IC50 | = | 27700.0 | nM | 4.56 |