Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4678540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assay
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Poly [ADP-ribose] polymerase 2 (CHEMBL5366) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.
Wang H,Ren B,Liu Y,Jiang B,Guo Y,Wei M,Luo L,Kuang X,Qiu M,Lv L,Xu H,Qi R,Yan H,Xu D,Wang Z,Huo CX,Zhu Y,Zhao Y,Wu Y,Qin Z,Su D,Tang T,Wang F,Sun X,Feng Y,Peng H,Wang X,Gao Y,Liu Y,Gong W,Yu F,Liu X,Wang L,Zhou C
J Med Chem (2020) 63 : 15541 -15563
PubMed 33264017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 9.08 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3984980 — — 1 9.70
CHEMBL3975917 — — 1 9.52
CHEMBL3929889 — — 1 9.52
CHEMBL3926240 — — 1 9.52
CHEMBL521686 OLAPARIB 4.0 1 9.40
CHEMBL3972156 — — 1 9.22
CHEMBL3925115 — — 1 9.15
CHEMBL3962648 — — 1 9.15
CHEMBL3929705 — — 1 9.10
CHEMBL3907535 — — 1 9.10
CHEMBL4112930 PAMIPARIB 3.0 1 9.05
CHEMBL3970252 — — 1 9.00
CHEMBL3969742 — — 1 8.96
CHEMBL3910080 — — 1 8.89
CHEMBL3900548 — — 1 8.74
CHEMBL3891329 — — 1 8.72
CHEMBL3940569 — — 1 7.68
CHEMBL3906623 — — 1 -
CHEMBL3954603 — — 1 -
CHEMBL3906567 — — 1 -
CHEMBL3895581 — — 1 -
CHEMBL3901638 — — 1 -
CHEMBL3961684 — — 1 -
CHEMBL4778454 — — 1 -
CHEMBL4753364 — — 1 -
CHEMBL4784831 — — 1 -
CHEMBL3916191 — — 1 -
CHEMBL4788782 — — 1 -
CHEMBL3983247 — — 1 -
CHEMBL3914932 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3984980 — IC50 = 0.2 nM 9.70
CHEMBL3975917 — IC50 = 0.3 nM 9.52
CHEMBL3926240 — IC50 = 0.3 nM 9.52
CHEMBL3929889 — IC50 = 0.3 nM 9.52
CHEMBL521686 OLAPARIB IC50 = 0.4 nM 9.40
CHEMBL3972156 — IC50 = 0.6 nM 9.22
CHEMBL3925115 — IC50 = 0.7 nM 9.15
CHEMBL3962648 — IC50 = 0.7 nM 9.15
CHEMBL3929705 — IC50 = 0.8 nM 9.10
CHEMBL3907535 — IC50 = 0.8 nM 9.10
CHEMBL4112930 PAMIPARIB IC50 = 0.9 nM 9.05
CHEMBL3970252 — IC50 = 1.0 nM 9.00
CHEMBL3969742 — IC50 = 1.1 nM 8.96
CHEMBL3910080 — IC50 = 1.3 nM 8.89
CHEMBL3900548 — IC50 = 1.8 nM 8.74
CHEMBL3891329 — IC50 = 1.9 nM 8.72
CHEMBL3940569 — IC50 = 21.0 nM 7.68
CHEMBL3922789 — IC50 - — -
CHEMBL3976904 — IC50 - — -
CHEMBL3931972 — IC50 - — -
CHEMBL3905389 — IC50 - — -
CHEMBL3952984 — IC50 - — -
CHEMBL3910594 — IC50 - — -
CHEMBL4776661 — IC50 - — -
CHEMBL3970120 — IC50 - — -
CHEMBL3931542 — IC50 - — -
CHEMBL3908092 — IC50 - — -
CHEMBL3908123 — IC50 - — -
CHEMBL3917078 — IC50 - — -
CHEMBL3947623 — IC50 - — -
CHEMBL4749094 — IC50 - — -
CHEMBL3905040 — IC50 - — -
CHEMBL3983342 — IC50 - — -
CHEMBL4784831 — IC50 - — -
CHEMBL3906623 — IC50 - — -
CHEMBL3954603 — IC50 - — -
CHEMBL3906567 — IC50 - — -
CHEMBL3895581 — IC50 - — -
CHEMBL3901638 — IC50 - — -
CHEMBL3961684 — IC50 - — -
CHEMBL4778454 — IC50 - — -
CHEMBL4753364 — IC50 - — -
CHEMBL4748572 — IC50 - — -
CHEMBL3916191 — IC50 - — -
CHEMBL4788782 — IC50 - — -
CHEMBL3983247 — IC50 - — -
CHEMBL3914932 — IC50 - — -
CHEMBL3901034 — IC50 - — -
CHEMBL3911687 — IC50 - — -
CHEMBL4749300 — IC50 - — -