Assay Detail
Binding
CHEMBL4678699
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Inhibition of recombinant human ACSL1 assessed as reduction in acetyl-coA prodution incubated for 90 mins in presence of Coenzyme A, ATP and MgCl2 by MALDI-TOF MS analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Long-chain-fatty-acid--CoA ligase 1 (CHEMBL4295746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764916 | — | — | 1 | 8.52 |
| CHEMBL4750346 | — | — | 1 | 7.89 |
| CHEMBL4746996 | — | — | 1 | 7.89 |
| CHEMBL4787746 | — | — | 1 | 7.55 |
| CHEMBL4749130 | — | — | 1 | 7.47 |
| CHEMBL4781788 | — | — | 1 | 7.41 |
| CHEMBL4778736 | — | — | 1 | 7.38 |
| CHEMBL4797544 | — | — | 1 | 7.36 |
| CHEMBL4755109 | — | — | 1 | 7.35 |
| CHEMBL4748671 | — | — | 1 | 7.33 |
| CHEMBL4740366 | — | — | 1 | 7.33 |
| CHEMBL4783346 | — | — | 1 | 6.82 |
| CHEMBL4800541 | — | — | 1 | 6.72 |
| CHEMBL4757253 | — | — | 1 | 6.62 |
| CHEMBL4757057 | — | — | 1 | 6.40 |
| CHEMBL4748493 | — | — | 1 | 6.22 |
| CHEMBL4751045 | — | — | 1 | 6.02 |
| CHEMBL4787809 | — | — | 1 | 5.72 |
| CHEMBL4800499 | — | — | 1 | 5.36 |
| CHEMBL4746718 | — | — | 1 | 5.34 |
| CHEMBL4752206 | — | — | 1 | 5.11 |
| CHEMBL4791698 | — | — | 1 | 4.77 |
| CHEMBL4754540 | — | — | 1 | 4.39 |
| CHEMBL4747319 | — | — | 1 | 4.29 |
| CHEMBL4745357 | — | — | 1 | 4.21 |
| CHEMBL4746709 | — | — | 1 | 4.11 |
| CHEMBL4744155 | — | — | 1 | - |
| CHEMBL4744967 | — | — | 1 | - |
| CHEMBL4785177 | — | — | 1 | - |
| CHEMBL4761105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764916 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4750346 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4746996 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4787746 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4749130 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4781788 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4778736 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4797544 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4755109 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4748671 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4740366 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4783346 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4800541 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4757253 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4757057 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4748493 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4751045 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4787809 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4800499 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4746718 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4752206 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4791698 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4754540 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4747319 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4745357 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4746709 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4744155 | — | IC50 | = | 141000.0 | nM | - |
| CHEMBL4744967 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4785177 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4761105 | — | IC50 | > | 200000.0 | nM | - |