Assay Detail
Binding
CHEMBL4678700
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Inhibition of ACSL1 (unknown origin) assessed as reduction in acetyl-coA prodution incubated for 90 mins in presence of Coenzyme A, ATP and MgCl2 by MALDI-TOF MS analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Long-chain-fatty-acid--CoA ligase 1 (CHEMBL4295746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.91 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761388 | — | — | 1 | 6.62 |
| CHEMBL4776019 | — | — | 1 | 6.51 |
| CHEMBL222502 | — | — | 1 | 5.77 |
| CHEMBL4751846 | — | — | 1 | 4.75 |
| CHEMBL4749993 | — | — | 1 | - |
| CHEMBL4792940 | — | — | 1 | - |
| CHEMBL4798042 | — | — | 1 | - |
| CHEMBL4789782 | — | — | 1 | - |
| CHEMBL4757253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761388 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4776019 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL222502 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4751846 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4749993 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4792940 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4798042 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4789782 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4757253 | — | IC50 | > | 200000.0 | nM | - |