Assay Detail
Binding
CHEMBL4678772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NF-kappaB activation in mouse RaW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs by Griess reagent based assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3α-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-κB and MAPK Pathway in LPS-Stimulated Macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.50 | 4.69 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746391 | — | — | 2 | 4.69 |
| CHEMBL489140 | KAURENOIC ACID | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746391 | — | IC50 | = | 20340.0 | nM | 4.69 |
| CHEMBL489140 | KAURENOIC ACID | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4746391 | — | Inhibition | - | % | - |