Assay Detail

CHEMBL4678914

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Binding

Inhibition of JNK1 (unknown origin) in presence of 5 mM ATP

ChEMBL ↗

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Target

Mitogen-activated protein kinase 8 (CHEMBL2276) ↗

Open DB target context

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Mitogen-activated protein kinase 8 (CHEMBL2276) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mitogen-activated protein kinase 8

CHEMBL2276

Anchored from Assay target.

Protein identity Mitogen-activated protein kinase 8

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Mitogen-activated protein kinase 8 (CHEMBL2276) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.

Barlaam B,Casella R,Cidado J,Cook C,De Savi C,Dishington A,Donald CS,Drew L,Ferguson AD,Ferguson D,Glossop S,Grebe T,Gu C,Hande S,Hawkins J,Hird AW,Holmes J,Horstick J,Jiang Y,Lamb ML,McGuire TM,Moore JE,O'Connell N,Pike A,Pike KG,Proia T,Roberts B,San Martin M,Sarkar U,Shao W,Stead D,Sumner N,Thakur K,Vasbinder MM,Varnes JG,Wang J,Wang L,Wu D,Wu L,Yang B,Yao T
J Med Chem (2020) 63 : 15564 -15590
PubMed 33306391 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.55	5.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4462530	ZEMIRCICLIB	2.0	1	5.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4462530	ZEMIRCICLIB	IC50	=	2800.0	nM	5.55