Assay Detail
Functional
CHEMBL4678938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplatelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 5 mins followed by ADP addition measured every 1 min for up to 6 mins by microplate reader analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y and P2Y as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.05 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786038 | — | — | 1 | 5.41 |
| CHEMBL4765165 | — | — | 1 | 5.37 |
| CHEMBL2333770 | — | — | 1 | 5.26 |
| CHEMBL4759436 | — | — | 1 | 5.23 |
| CHEMBL4744741 | — | — | 1 | 5.23 |
| CHEMBL4740238 | — | — | 1 | 5.23 |
| CHEMBL4758824 | — | — | 1 | 5.21 |
| CHEMBL4756830 | — | — | 1 | 5.21 |
| CHEMBL4740089 | — | — | 1 | 5.20 |
| CHEMBL4750778 | — | — | 1 | 5.20 |
| CHEMBL4763820 | — | — | 1 | 5.20 |
| CHEMBL4785014 | — | — | 1 | 5.18 |
| CHEMBL4761009 | — | — | 1 | 5.17 |
| CHEMBL4786508 | — | — | 1 | 5.17 |
| CHEMBL4752123 | — | — | 1 | 5.17 |
| CHEMBL4755153 | — | — | 1 | 5.17 |
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 5.14 |
| CHEMBL4789758 | — | — | 1 | 5.10 |
| CHEMBL4757679 | — | — | 1 | 5.06 |
| CHEMBL4762718 | — | — | 1 | 5.06 |
| CHEMBL4783961 | — | — | 1 | 5.05 |
| CHEMBL4764917 | — | — | 1 | 5.04 |
| CHEMBL4751070 | — | — | 1 | 5.03 |
| CHEMBL4752582 | — | — | 1 | 5.03 |
| CHEMBL4795315 | — | — | 1 | 5.02 |
| CHEMBL4748245 | — | — | 1 | 4.95 |
| CHEMBL4798473 | — | — | 1 | 4.87 |
| CHEMBL4745444 | — | — | 1 | 4.83 |
| CHEMBL3628192 | — | — | 1 | 4.80 |
| CHEMBL4763814 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786038 | — | IC50 | = | 3875.0 | nM | 5.41 |
| CHEMBL4765165 | — | IC50 | = | 4237.0 | nM | 5.37 |
| CHEMBL2333770 | — | IC50 | = | 5537.0 | nM | 5.26 |
| CHEMBL4759436 | — | IC50 | = | 5879.0 | nM | 5.23 |
| CHEMBL4744741 | — | IC50 | = | 5934.0 | nM | 5.23 |
| CHEMBL4740238 | — | IC50 | = | 5856.0 | nM | 5.23 |
| CHEMBL4758824 | — | IC50 | = | 6238.0 | nM | 5.21 |
| CHEMBL4756830 | — | IC50 | = | 6196.0 | nM | 5.21 |
| CHEMBL4740089 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL4750778 | — | IC50 | = | 6311.0 | nM | 5.20 |
| CHEMBL4763820 | — | IC50 | = | 6247.0 | nM | 5.20 |
| CHEMBL4785014 | — | IC50 | = | 6563.0 | nM | 5.18 |
| CHEMBL4755153 | — | IC50 | = | 6736.0 | nM | 5.17 |
| CHEMBL4752123 | — | IC50 | = | 6796.0 | nM | 5.17 |
| CHEMBL4786508 | — | IC50 | = | 6826.0 | nM | 5.17 |
| CHEMBL4761009 | — | IC50 | = | 6825.0 | nM | 5.17 |
| CHEMBL398435 | TICAGRELOR | IC50 | = | 7213.0 | nM | 5.14 |
| CHEMBL4789758 | — | IC50 | = | 7987.0 | nM | 5.10 |
| CHEMBL4757679 | — | IC50 | = | 8705.0 | nM | 5.06 |
| CHEMBL4762718 | — | IC50 | = | 8754.0 | nM | 5.06 |
| CHEMBL4783961 | — | IC50 | = | 8987.0 | nM | 5.05 |
| CHEMBL4764917 | — | IC50 | = | 9134.0 | nM | 5.04 |
| CHEMBL4751070 | — | IC50 | = | 9259.0 | nM | 5.03 |
| CHEMBL4752582 | — | IC50 | = | 9376.0 | nM | 5.03 |
| CHEMBL4795315 | — | IC50 | = | 9466.0 | nM | 5.02 |
| CHEMBL4748245 | — | IC50 | = | 11352.0 | nM | 4.95 |
| CHEMBL4798473 | — | IC50 | = | 13353.0 | nM | 4.87 |
| CHEMBL4745444 | — | IC50 | = | 14857.0 | nM | 4.83 |
| CHEMBL3628192 | — | IC50 | = | 15727.0 | nM | 4.80 |
| CHEMBL4763814 | — | IC50 | = | 16825.0 | nM | 4.77 |
| CHEMBL4761960 | — | IC50 | = | 17636.0 | nM | 4.75 |
| CHEMBL4777430 | — | IC50 | = | 19357.0 | nM | 4.71 |
| CHEMBL4777954 | — | IC50 | = | 22136.0 | nM | 4.66 |
| CHEMBL4797190 | — | IC50 | = | 22358.0 | nM | 4.65 |
| CHEMBL4759062 | — | IC50 | = | 24590.0 | nM | 4.61 |
| CHEMBL4792726 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4745419 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4755341 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4762246 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4742313 | — | IC50 | > | 30000.0 | nM | - |