Assay Detail
Binding
CHEMBL4678939
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Antagonist activity at P2Y1 in rabbit platelet-rich plasma assessed as inhibition of ADP-induced increase in intracellular Ca2+ concentration preincubated for 5 mins followed by ADP addition and measured for 3 mins by fluo4 dye-based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y and P2Y as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.56 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786038 | — | — | 1 | 5.59 |
| CHEMBL2333770 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786038 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL2333770 | — | IC50 | = | 3030.0 | nM | 5.52 |