Assay Detail
Binding
CHEMBL4678991
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Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.38 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779819 | — | — | 1 | 8.18 |
| CHEMBL4779945 | — | — | 1 | 8.12 |
| CHEMBL4788892 | — | — | 1 | 8.03 |
| CHEMBL4759641 | — | — | 1 | 7.77 |
| CHEMBL4751226 | — | — | 1 | 7.58 |
| CHEMBL4784233 | — | — | 1 | 7.41 |
| CHEMBL2086911 | — | — | 1 | 7.32 |
| CHEMBL4747530 | — | — | 1 | 7.28 |
| CHEMBL4762752 | — | — | 1 | 6.96 |
| CHEMBL4797684 | — | — | 1 | 6.77 |
| CHEMBL2086892 | — | — | 1 | 6.57 |
| CHEMBL2086910 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779819 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4779945 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL4788892 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL4759641 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4751226 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4784233 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL2086911 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4747530 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL4762752 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4797684 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2086892 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2086910 | — | Ki | = | 280.0 | nM | 6.55 |