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Assay Detail

CHEMBL4679265

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human sEH expressed in baculovirus expression system using MNPC as substrate by fluorescence-based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain.
Singh N,Barnych B,Morisseau C,Wagner KM,Wan D,Takeshita A,Pham H,Xu T,Dandekar A,Liu JY,Hammock BD
J Nat Prod (2020) 83 : 3689 -3697
PubMed 33320645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.74 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4744679 1 7.82
CHEMBL4749954 1 7.75
CHEMBL4753325 1 7.26
CHEMBL4756519 1 7.20
CHEMBL2413162 1 7.12
CHEMBL4779803 1 7.08
CHEMBL2413160 1 7.04
CHEMBL4795105 1 6.98
CHEMBL4783862 1 6.96
CHEMBL4797803 1 6.91
CHEMBL2413161 1 6.87
CHEMBL2415106 1 6.81
CHEMBL2415103 1 6.63
CHEMBL2415105 1 6.62
CHEMBL2415102 1 6.28
CHEMBL1223510 1 6.05
CHEMBL4762433 1 5.15
CHEMBL4742239 1 4.79
CHEMBL2415104 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4744679 IC50 = 15.0 nM 7.82
CHEMBL4749954 IC50 = 18.0 nM 7.75
CHEMBL4753325 IC50 = 55.0 nM 7.26
CHEMBL4756519 IC50 = 63.0 nM 7.20
CHEMBL2413162 IC50 = 76.0 nM 7.12
CHEMBL4779803 IC50 = 84.0 nM 7.08
CHEMBL2413160 IC50 = 92.0 nM 7.04
CHEMBL4795105 IC50 = 104.0 nM 6.98
CHEMBL4783862 IC50 = 111.0 nM 6.96
CHEMBL4797803 IC50 = 123.0 nM 6.91
CHEMBL2413161 IC50 = 134.0 nM 6.87
CHEMBL2415106 IC50 = 155.0 nM 6.81
CHEMBL2415103 IC50 = 235.0 nM 6.63
CHEMBL2415105 IC50 = 241.0 nM 6.62
CHEMBL2415102 IC50 = 524.0 nM 6.28
CHEMBL1223510 IC50 = 893.0 nM 6.05
CHEMBL4762433 IC50 = 7059.0 nM 5.15
CHEMBL4742239 IC50 = 16077.0 nM 4.79
CHEMBL2415104 IC50 > 100000.0 nM -