Assay Detail
Functional
CHEMBL4679459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 UC-1075 infected in African green monkey Vero cells assessed as reduction in virus plaque formation measured on day 5 post-viral infection by microscopic analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.19 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749149 | — | — | 1 | 7.02 |
| CHEMBL4751829 | — | — | 1 | 6.14 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.82 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 5.76 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | 3.0 | 1 | - |
| CHEMBL4764621 | — | — | 1 | - |
| CHEMBL4788593 | — | — | 1 | - |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749149 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4751829 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | EC50 | > | 12.8 | nM | - |
| CHEMBL4764621 | — | EC50 | >= | 55100.0 | nM | - |
| CHEMBL4788593 | — | EC50 | >= | 86200.0 | nM | - |
| CHEMBL888 | GEMCITABINE | EC50 | > | 1.6 | nM | - |