Assay Detail
Binding
CHEMBL4679831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as substrate preincubated with enzyme for 12 mins and measured after 35 mins in presence of ATP by fluorescence-based microfluidic mobility shift assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potential of Cyclin-Dependent Kinase Inhibitors as Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.95 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446357 | EBVACICLIB | 2.0 | 1 | 10.10 |
| CHEMBL4750658 | — | — | 1 | 9.89 |
| CHEMBL4745424 | — | — | 1 | 9.74 |
| CHEMBL4796501 | — | — | 1 | 9.51 |
| CHEMBL4748471 | — | — | 1 | 9.07 |
| CHEMBL4747638 | — | — | 1 | 9.06 |
| CHEMBL4798327 | — | — | 1 | 9.02 |
| CHEMBL4757341 | — | — | 1 | 8.75 |
| CHEMBL4797526 | — | — | 1 | 8.70 |
| CHEMBL4755392 | — | — | 1 | 8.65 |
| CHEMBL4752291 | — | — | 1 | 8.54 |
| CHEMBL4753883 | — | — | 1 | 8.15 |
| CHEMBL4800105 | — | — | 1 | 8.04 |
| CHEMBL4763871 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446357 | EBVACICLIB | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL4750658 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL4745424 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL4796501 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL4748471 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL4747638 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL4798327 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL4757341 | — | Ki | = | 1.77 | nM | 8.75 |
| CHEMBL4797526 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL4755392 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL4752291 | — | Ki | = | 2.91 | nM | 8.54 |
| CHEMBL4753883 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4800105 | — | Ki | = | 9.15 | nM | 8.04 |
| CHEMBL4763871 | — | Ki | = | 9.59 | nM | 8.02 |