Assay Detail

CHEMBL4679938

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ADMET

Inhibition of alpha1 nAChR (unknown origin)

ChEMBL ↗

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Target

Acetylcholine receptor subunit alpha (CHEMBL4808) ↗

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Acetylcholine receptor subunit alpha (CHEMBL4808) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Acetylcholine receptor subunit alpha

CHEMBL4808

Anchored from Assay target.

Protein identity Acetylcholine receptor subunit alpha

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Acetylcholine receptor subunit alpha (CHEMBL4808) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.

Cherney EC,Zhang L,Nara S,Zhu X,Gullo-Brown J,Maley D,Lin TA,Hunt JT,Huang C,Yang Z,Darienzo C,Discenza L,Ranasinghe A,Grubb M,Ziemba T,Traeger SC,Li X,Johnston K,Kopcho L,Fereshteh M,Foster K,Stefanski K,Fargnoli J,Swanson J,Brown J,Delpy D,Seitz SP,Borzilleri R,Vite G,Balog A
ACS Med Chem Lett (2021) 12 : 288 -294
PubMed 33603977 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.91	4.91

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4786690	—	—	1	4.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4786690	—	IC50	=	12300.0	nM	4.91