Assay Detail
Binding
CHEMBL4680002
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Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by IFNgamma stimulation and measured after 18 hrs by
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | M109 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786690 | — | — | 1 | 8.70 |
| CHEMBL4743409 | — | — | 1 | 8.52 |
| CHEMBL4161733 | — | — | 1 | 8.30 |
| CHEMBL4755937 | — | — | 1 | 7.92 |
| CHEMBL4747228 | — | — | 1 | 7.70 |
| CHEMBL4757725 | — | — | 1 | 7.32 |
| CHEMBL4793928 | — | — | 1 | 7.25 |
| CHEMBL4794508 | — | — | 1 | 7.21 |
| CHEMBL4754556 | — | — | 1 | 7.17 |
| CHEMBL4740285 | — | — | 1 | 7.07 |
| CHEMBL4789681 | — | — | 1 | 7.04 |
| CHEMBL4796405 | — | — | 1 | 6.67 |
| CHEMBL4757067 | — | — | 1 | 6.54 |
| CHEMBL4759322 | — | — | 1 | 6.19 |
| CHEMBL4791270 | — | — | 1 | 6.11 |
| CHEMBL4758055 | — | — | 1 | 6.06 |
| CHEMBL4752360 | — | — | 1 | - |
| CHEMBL4791151 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786690 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4743409 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4161733 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4755937 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4747228 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4757725 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4793928 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4794508 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4754556 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4740285 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4789681 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4796405 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL4757067 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4759322 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL4791270 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL4758055 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4752360 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4791151 | — | IC50 | > | 1000.0 | nM | - |