Assay Detail
Functional
CHEMBL4680970
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Antiplasmodial activity against Plasmodium berghei ookinete form assessed as growth inhibition incubated for 22 hrs by GFP-based fluorescence microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.07 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091762 | CABAMIQUINE | 2.0 | 1 | 8.30 |
| CHEMBL4781713 | — | — | 1 | 8.30 |
| CHEMBL4764214 | — | — | 1 | 7.85 |
| CHEMBL4783407 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091762 | CABAMIQUINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4781713 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4764214 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4783407 | — | EC50 | = | 15.0 | nM | 7.82 |