Assay Detail
Functional
CHEMBL4680972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.96 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.10 |
| CHEMBL4091762 | CABAMIQUINE | 2.0 | 1 | 7.62 |
| CHEMBL4764214 | — | — | 1 | 7.41 |
| CHEMBL4781713 | — | — | 1 | 6.98 |
| CHEMBL4783407 | — | — | 1 | 6.82 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 5.51 |
| CHEMBL298470 | TAFENOQUINE | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4091762 | CABAMIQUINE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4764214 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4781713 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4783407 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL35228 | PYRONARIDINE | EC50 | = | 3108.0 | nM | 5.51 |
| CHEMBL298470 | TAFENOQUINE | EC50 | = | 5250.0 | nM | 5.28 |