Assay Detail
ADMET
CHEMBL4680974
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Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 68 hrs by resazurin dye based fluorescence assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 4.74 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4800400 | — | — | 1 | 5.22 |
| CHEMBL4760148 | — | — | 1 | 5.16 |
| CHEMBL4784227 | — | — | 1 | 5.16 |
| CHEMBL4742384 | — | — | 1 | 5.10 |
| CHEMBL4747859 | — | — | 1 | 5.05 |
| CHEMBL4740773 | — | — | 1 | 5.05 |
| CHEMBL4749067 | — | — | 1 | 5.00 |
| CHEMBL4781713 | — | — | 1 | 4.89 |
| CHEMBL4798637 | — | — | 1 | 4.89 |
| CHEMBL4745414 | — | — | 1 | 4.77 |
| CHEMBL4781034 | — | — | 1 | 4.72 |
| CHEMBL4755190 | — | — | 1 | 4.72 |
| CHEMBL4789980 | — | — | 1 | 4.70 |
| CHEMBL3637888 | — | — | 1 | 4.68 |
| CHEMBL4789144 | — | — | 1 | 4.68 |
| CHEMBL4783407 | — | — | 1 | 4.68 |
| CHEMBL4091762 | CABAMIQUINE | 2.0 | 1 | 4.62 |
| CHEMBL4750855 | — | — | 1 | 4.60 |
| CHEMBL4785303 | — | — | 1 | 4.58 |
| CHEMBL4764214 | — | — | 1 | 4.51 |
| CHEMBL4756468 | — | — | 1 | 4.39 |
| CHEMBL4799086 | — | — | 1 | 4.39 |
| CHEMBL4743214 | — | — | 1 | 4.39 |
| CHEMBL4780190 | — | — | 1 | 4.30 |
| CHEMBL4745218 | — | — | 1 | 4.30 |
| CHEMBL4756596 | — | — | 1 | - |
| CHEMBL4748314 | — | — | 1 | - |
| CHEMBL4743613 | — | — | 1 | - |
| CHEMBL4757727 | — | — | 1 | - |
| CHEMBL4763266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4800400 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4760148 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4784227 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4742384 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4747859 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4740773 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4749067 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4781713 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4798637 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4745414 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4781034 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4755190 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4789980 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3637888 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4783407 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4789144 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4091762 | CABAMIQUINE | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4750855 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4785303 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4764214 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4743214 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4799086 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4756468 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4780190 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4745218 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4756596 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4748314 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4743613 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4757727 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4763266 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4776095 | — | EC50 | > | 50000.0 | nM | - |