Assay Detail
Binding
CHEMBL4681202
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Agonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-24 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.32 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289605 | — | — | 1 | 7.96 |
| CHEMBL3289604 | — | — | 1 | 7.26 |
| CHEMBL4764510 | — | — | 1 | 6.73 |
| CHEMBL3289606 | — | — | 1 | - |
| CHEMBL4777693 | — | — | 1 | - |
| CHEMBL4782288 | — | — | 1 | - |
| CHEMBL4797755 | — | — | 1 | - |
| CHEMBL4755971 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289605 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3289604 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4764510 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3289606 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4777693 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4782288 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4797755 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4755971 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL88478 | — | EC50 | - | — | - | |
| CHEMBL916 | TIROFIBAN | EC50 | - | — | - |